| Expression pattern: |
UP |
| Associated gene: |
MORC2 |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
promotes proliferation; promotes colony formation; promotes migration; promotes invasion; inhibits apoptosis; promotes tumor growth; promotes glutamine metabolism |
| Molecular mechanism: |
circDNM3OS acts as a ceRNA sponge for miR-145-5p to upregulate MORC2, thereby promoting malignancy and glutamine metabolism in cholangiocarcinoma. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glutaminolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
High circDNM3OS expression was associated with tumor size, TNM stage, and lymph node invasion in CCA patients. |
| Description: |
circDNM3OS is up-regulated in cholangiocarcinoma tissues and cells and mainly localizes to the cytoplasm. It promotes tumor growth and malignant phenotypes (proliferation, migration/invasion) and enhances glutamine metabolism by sponging miR-145-5p to upregulate MORC2. |
| Confidence score: |
0.7637 |