circRNA basic information
circBase ID: -
Name: hsa_circ_SLC8A1
Synonym: circSLC8A1
Host Gene: SLC8A1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary glioma tissues; normal brain specimens
Cell lines:

HEB; U251MG; U87MG; SHG44; T98G
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: CDC27
Associated microRNA: miR-214-5p
Biological function: circSLC8A1 acts as a tumor suppressor in glioma and inhibits glioma cell proliferation and invasion.
Molecular mechanism: circSLC8A1 sponges miR-214-5p and regulates CDC27 through the miR-214-5p/CDC27 axis.
Biological pathway or process:

proliferation (inhibits); invasion (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot
Clinical significance:

-
Description:

circSLC8A1 is down-regulated in glioma tissues and glioma cell lines. Functionally, circSLC8A1 suppresses glioma cell proliferation and invasion. Mechanistically, circSLC8A1 sponges miR-214-5p and its tumor-suppressive effects are mediated through the miR-214-5p/CDC27 axis.
Confidence score:

0.6479
Other information
Title:

Circular RNA circSLC8A1 inhibits the proliferation and invasion of glioma cells through targeting the miR-214-5p/CDC27 axis.

Journal: Metabolic brain disease
Published: 2022
PubMed ID: 35098413
Study type:

combined biological and clinical study
Data availability: -
Code availability: -