| Expression pattern: |
UP |
| Associated gene: |
COL1A2, Ago2 |
| Associated microRNA: |
miR-92b-3p |
| Biological function: |
TGF-beta2-induced circ-PRDM5 promotes LEC viability, migration, invasion, and EMT in PCO models; circ-PRDM5 knockdown reduces TGF-beta2-induced migration, invasion, and EMT. |
| Molecular mechanism: |
circ-PRDM5 acts as a ceRNA by sponging miR-92b-3p, thereby increasing COL1A2 expression and promoting TGF-beta2-induced migration, invasion, and EMT in LECs. |
| Biological pathway or process: |
ceRNA regulation (promotes); migration (promotes); invasion (promotes); EMT (promotes); proliferation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; Transwell Assay; Wound Healing Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ-PRDM5 might be a potential therapeutic target for PCO. |
| Description: |
circ-PRDM5 is up-regulated in PCO tissues and TGF-beta2-stimulated human lens epithelial cells. It promotes LEC viability, migration, invasion, and EMT by acting as a miR-92b-3p sponge to increase COL1A2 expression, suggesting a potential therapeutic role in PCO. |
| Confidence score: |
0.7785 |