| Expression pattern: |
UP |
| Associated gene: |
HOXA13 |
| Associated microRNA: |
miR-1249-3p |
| Biological function: |
promotes cell proliferation, cycle progression, migration, invasion, EMT and tumor growth; inhibits miR-1249-3p |
| Molecular mechanism: |
ceRNA mechanism |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Transfection; CCK8; EdU Staining; Cell Cycle Assay; Transwell Assay; Western Blot; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Patients with low expression of circ_0010235 had a longer survival time than those with high circ_0010235 expression. |
| Description: |
circ_0010235 is upregulated in LUAD and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT, and tumor growth by sponging miR-1249-3p and relieving repression of HOXA13. |
| Confidence score: |
0.8708 |