| Expression pattern: |
UP |
| Associated gene: |
FBN1, ADAM22, beta-catenin, c-Myc |
| Associated microRNA: |
miR-342-3p |
| Biological function: |
promotes doxorubicin resistance (chemoresistance), promotes proliferation, inhibits apoptosis in osteosarcoma |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-342-3p, thereby relieving miR-342-3p-mediated repression of FBN1 and activating Wnt/beta-catenin signaling to promote doxorubicin resistance. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis; In Vivo Animal Model |
| Clinical significance: |
High expression of has_circ_0004674 was associated with Enneking stage and chemoresistance in OS patients. |
| Description: |
hsa_circ_0004674 is upregulated in doxorubicin-resistant osteosarcoma tissues and cells and promotes doxorubicin chemoresistance. Mechanistically, it sponges miR-342-3p to upregulate FBN1 and activate Wnt/beta-catenin signaling, thereby enhancing resistance and malignant phenotypes (proliferation, reduced apoptosis). |
| Confidence score: |
0.8118 |