circRNA basic information
circBase ID: -
Name: hsa_circ_TTBK2
Synonym: circTTBK2
Host Gene: TTBK2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005076
MONDO name: periodontitis
Disease details: periodontitis
Disease DO ID:
 824, 9893
Disease MeSH ID:
 D010518
Disease NCIt ID:
 C34918
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

gingival tissues; gingiva biopsy samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: COL1A1, ACVR2B, C22orf46, CACNA1C, CD200, CHST6, CNTNAP1, DAAM2, DTX3
Associated microRNA: miR-6749-3p, miR-4279
Biological function: Predicted to contribute to Redondoviridae-infected periodontitis through a ceRNA axis involving miR-6749-3p and COL1A1.
Molecular mechanism: Predicted miRNA sponge/ceRNA mechanism involving miR-6749-3p, miR-4279 and target mRNAs including COL1A1.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential diagnostic marker and therapeutic target for virus-related periodontal lesions.
Description:

circTTBK2 is up-regulated in Redondoviridae-positive periodontitis gingival tissues and was validated by qRT-PCR. The study predicts that circTTBK2 may participate in a ceRNA axis, especially circTTBK2-hsa-miR-6749-3p-COL1A1, relevant to Redondoviridae-infected periodontitis.
Confidence score:

0.4032
Other information
Title:

Redondoviridae infection regulates circRNAome in periodontitis.

Journal: Journal of medical virology
Published: 2022
PubMed ID: 35075668
Study type:

combined clinical and bioinformatics study
Data availability: GSE189022
Code availability: -