circRNA basic information
circBase ID: hsa_circ_0007786
Name: hsa_circ_PTK2
Synonym: circPTK2
Host Gene: PTK2
Genomic location(hg19): chr8:141840570-141900868:-
Genomic location(hg38): chr8:140830471-140890769:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005076
MONDO name: periodontitis
Disease details: periodontitis
Disease DO ID:
 824, 9893
Disease MeSH ID:
 D010518
Disease NCIt ID:
 C34918
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

gingival tissues; gingiva biopsy samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Identified as an up-regulated key circRNA associated with the pathobiology of Redondoviridae-related periodontitis.
Molecular mechanism: Predicted circRNA-miRNA-mRNA network mechanism, but specific miRNA and mRNA partners were not provided in the supplied text.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential diagnostic marker and therapeutic target for virus-related periodontal lesions.
Description:

circPTK2 is reported as a key circRNA associated with Redondoviridae-related periodontitis and was validated by qRT-PCR among the selected differentially expressed circRNAs. It was incorporated into predicted circRNA-miRNA-mRNA network analyses, although specific partners were not detailed in the supplied text.
Confidence score:

0.4032
Other information
Title:

Redondoviridae infection regulates circRNAome in periodontitis.

Journal: Journal of medical virology
Published: 2022
PubMed ID: 35075668
Study type:

combined clinical and bioinformatics study
Data availability: GSE189022
Code availability: -