| Expression pattern: |
UP |
| Associated gene: |
MMP2, COL6A2, COL8A2, NFATC4, BET1L, RNF24 |
| Associated microRNA: |
miR-6754-5p, miR-205-5p |
| Biological function: |
Predicted to contribute to the etiopathogenesis and development of Redondoviridae-related periodontitis. |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA ceRNA mechanism involving miR-6754-5p/miR-205-5p and target mRNAs. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Potential diagnostic marker and therapeutic target for virus-related periodontal lesions. |
| Description: |
circCOL1A1 is up-regulated in periodontitis gingival tissues and was highlighted as a key circRNA in Redondoviridae-related periodontitis. The study predicts that circCOL1A1 may act through a ceRNA network involving miR-6754-5p/miR-205-5p and target mRNAs such as MMP2. |
| Confidence score: |
0.348 |