| Expression pattern: |
UP |
| Associated gene: |
TUFT1, Ago2 |
| Associated microRNA: |
miR-485-5p |
| Biological function: |
Promotes DDP resistance, cell proliferation, colony formation, migration, and tumor growth, and inhibits apoptosis in DDP-resistant cervical cancer. |
| Molecular mechanism: |
circ_0074269 acts as a ceRNA sponge for miR-485-5p, thereby upregulating TUFT1 expression and promoting DDP resistance; it can also be delivered via exosomes. |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Western Blot; TUNEL; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ_0074269 is proposed as a potential treatment target for cervical cancer and is associated with DDP resistance. |
| Description: |
Hsa_circ_0074269/circ_0074269 is upregulated in DDP-resistant cervical cancer samples, cells, and exosomes. It promotes cisplatin resistance, tumor growth, proliferation, and migration while suppressing apoptosis through a ceRNA mechanism involving miR-485-5p-mediated regulation of TUFT1. The study supports circ_0074269 as a potential therapeutic target for overcoming DDP resistance in cervical cancer. |
| Confidence score: |
0.8175 |