| Expression pattern: |
UP |
| Associated gene: |
USP7 |
| Associated microRNA: |
miR-654-3p |
| Biological function: |
Promotes LSCC cell proliferation, cell cycle progression, migration, invasion, EMT and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_CORO1C acts as a miRNA sponge for miR-654-3p and regulates USP7 expression through the circ_CORO1C/miR-654-3p/USP7 axis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; MTT; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
Potential therapeutic target for LSCC. |
| Description: |
circ_CORO1C is up-regulated in LSCC tissues and cell lines. Functionally, circ_CORO1C promotes LSCC progression by enhancing proliferation, cell cycle progression, migration, invasion, EMT and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts through the miR-654-3p/USP7 regulatory axis. |
| Confidence score: |
0.786 |