| Expression pattern: |
UP |
| Associated gene: |
PRPS1, KIF2A |
| Associated microRNA: |
miR-377-3p |
| Biological function: |
circKIF2A promotes neuroblastoma cell proliferation, migration, invasion, metastasis, glycolysis, and tumor growth, and inhibits apoptosis; circKIF2A knockdown suppresses these malignant phenotypes and increases apoptosis. |
| Molecular mechanism: |
circKIF2A acts as a competing endogenous RNA by sponging miR-377-3p, thereby enhancing PRPS1 expression and promoting neuroblastoma progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); glycolysis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Transwell Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circKIF2A expression was associated with TNM stage, histological differentiation, and lymph node metastasis in pediatric neuroblastoma patients; the circKIF2A/miR-377-3p/PRPS1 axis may provide a new perspective for clinical diagnosis and treatment. |
| Description: |
circKIF2A is up-regulated in neuroblastoma tissues and cell lines and functions as an oncogenic circRNA. Its knockdown inhibits proliferation, migration, invasion, metastasis, glycolysis, and xenograft tumor growth while promoting apoptosis. Mechanistically, cytoplasmic circKIF2A sponges miR-377-3p to increase PRPS1 expression, forming a circKIF2A/miR-377-3p/PRPS1 ceRNA axis. |
| Confidence score: |
0.8443 |