circRNA basic information
circBase ID: hsa_circ_0005397
Name: hsa_circ_RHOT1
Synonym: -
Host Gene: RHOT1
Genomic location(hg19): chr17:30500849-30503232:+
Genomic location(hg38): chr17:32173830-32176213:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; tumor tissues; adjacent normal tissues
Cell lines:

SK-Hep1; SMMC-7721; BEL-7404; Huh7; LO2; BEL-7704; SMMC7721
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Plasma hsa_cic_0005397 yielded an AUC of 0.737 (95% CI, 0.671-0.795) for differentiating HCC from benign liver diseases and healthy controls; high plasma hsa_cic_0005397 was associated with larger tumor size and advanced TNM stage; increased plasma hsa_cic_0005397 correlated with shorter overall survival; dynamic monitoring decreased post-operation and increased in recurrence/metastasis.
Description:

Plasma hsa_circ_0005397 is up-regulated in HCC patients and is detectable and stable in plasma. It shows diagnostic value alone and higher sensitivity when combined with AFP and AFP-L3, and its high level is associated with advanced disease features and poorer overall survival; postoperative dynamics may indicate recurrence/metastasis.
Confidence score:

0.6888
Other information
Title:

Identification of Plasma hsa_circ_0005397 and Combined With Serum AFP, AFP-L3 as Potential Biomarkers for Hepatocellular Carcinoma.

Journal: Frontiers in pharmacology
Published: 2021
PubMed ID: 33679420
Study type:

combined biological and clinical study
Data availability: -
Code availability: -