| Expression pattern: |
UP |
| Associated gene: |
SRSF7, PDK1, Ago2, Ki-67, Bax, Bcl-2 |
| Associated microRNA: |
miR-924 |
| Biological function: |
Circ_0006006 promotes NSCLC cell proliferation, migration, invasion, angiogenesis and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
Circ_0006006 acts as a ceRNA by sponging miR-924, thereby increasing SRSF7 expression to facilitate NSCLC progression. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); cell cycle (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
Circ_0006006 may be an oncogenic circRNA and a potential molecular mechanism-related marker in NSCLC progression, but no diagnostic or prognostic performance was directly evaluated. |
| Description: |
Circ_0006006 is up-regulated in NSCLC tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-924 to increase SRSF7 expression, thereby promoting proliferation, migration, invasion, angiogenesis and tumor growth while suppressing apoptosis. |
| Confidence score: |
0.8299 |