| Expression pattern: |
DN |
| Associated gene: |
B4GALT3, AGO2 |
| Associated microRNA: |
miR-1247-3p |
| Biological function: |
inhibits proliferation; inhibits migration; inhibits invasion; suppresses tumor growth |
| Molecular mechanism: |
circUBXN7 acts as a ceRNA (miRNA sponge) for miR-1247-3p to relieve repression of B4GALT3, increasing B4GALT3 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
Decreased circUBXN7 expression was associated with pathological stage, grade and poor prognosis of BC patients. |
| Description: |
In bladder cancer, circUBXN7 is down-regulated and acts as a tumor suppressor. It sponges miR-1247-3p to increase B4GALT3 expression, thereby inhibiting proliferation, migration/invasion, and tumor growth; low circUBXN7 correlates with worse overall survival. |
| Confidence score: |
0.8836 |