circRNA basic information
circBase ID: -
Name: hsa_circ_LARP4
Synonym: circular RNA La-related protein 4
Host Gene: LARP4
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: nonsmall cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

BEAS-2B; NCI-H1299; NCI-H522; NCI-H23; NCI-H358; NCI-H1650; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-21-5p
Biological function: Inhibits NSCLC cell proliferation and promotes apoptosis.
Molecular mechanism: circ-LARP4 acts as a sponge for miR-21-5p, negatively regulates miR-21-5p, and thereby suppresses proliferation while enhancing apoptosis in NSCLC cells.
Biological pathway or process:

proliferation (inhibits); apoptosis (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Bioinformatics Analysis
Clinical significance:

-
Description:

circ-LARP4 is down-regulated in NSCLC cell lines relative to normal lung epithelial cells. Functional experiments indicate that circ-LARP4 suppresses NSCLC cell proliferation and promotes apoptosis, at least partly by directly binding and negatively regulating miR-21-5p.
Confidence score:

0.6263
Other information
Title:

Circular RNA La-Related Protein 4 Inhibits Non-Small Cell Lung Cancer Cell Proliferation While Promotes Apoptosis Through Sponging microRNA-21-5p.

Journal: Cancer biotherapy & radiopharmaceuticals
Published: 2022
PubMed ID: 32614609
Study type:

biological research
Data availability: The data set supporting the conclusions of this article is included within the article.
Code availability: -