| Expression pattern: |
UP |
| Associated gene: |
PDCD4 |
| Associated microRNA: |
miR-496 |
| Biological function: |
circ_0007290 promotes OGD-induced neuronal injury, apoptosis, LDH release, and inflammation; knockdown of circ_0007290 protects HCN-2 cells by restoring proliferation and reducing apoptosis and inflammatory cytokines. |
| Molecular mechanism: |
circ_0007290 functions as a ceRNA sponge for miR-496, relieving miR-496-mediated repression of PDCD4 and thereby regulating OGD-induced neuronal injury. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); apoptosis (promotes); inflammation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; ELISA; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_0007290 was elevated in plasma of AIS patients and correlated with WBC, HDL-C, LDL-C, and total cholesterol, suggesting association with AIS clinical characteristics. |
| Description: |
circ_0007290 is up-regulated in plasma from AIS patients and in OGD-treated HCN-2 cells. Its knockdown protects against OGD-induced neuronal injury by promoting cell proliferation and reducing LDH release, apoptosis, and inflammatory cytokines. Mechanistically, circ_0007290 sponges miR-496 to up-regulate PDCD4 in a circ_0007290/miR-496/PDCD4 ceRNA axis. |
| Confidence score: |
0.7893 |