| Expression pattern: |
UP |
| Associated gene: |
CDK6, SEC61A1 mRNA, PCNA, Snail, E-cadherin |
| Associated microRNA: |
miR-660-5p |
| Biological function: |
Circ_SEC61A1 promotes MM cell proliferation, colony formation, viability, migration, invasion, metastasis-related phenotypes and EMT, and inhibits apoptosis. |
| Molecular mechanism: |
Circ_SEC61A1 acts as a ceRNA/miRNA sponge for miR-660-5p, thereby positively regulating CDK6 expression and promoting MM progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; Transfection; Colony Formation Assay; EdU Staining; MTT; Western Blot; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
Circ_SEC61A1 might serve as a therapeutic target for MM patients. |
| Description: |
Circ_SEC61A1 is up-regulated in multiple myeloma tissues and cells and functions as an oncogenic circRNA. It mainly localizes in the cytoplasm, sponges miR-660-5p, and increases CDK6 expression, thereby promoting proliferation, migration, invasion, metastasis-related/EMT phenotypes and inhibiting apoptosis in MM cells. The study suggests circ_SEC61A1 may be a potential therapeutic target for MM. |
| Confidence score: |
0.742 |