circRNA basic information
circBase ID: hsa_circ_0085154
Name: hsa_circ_PABPC1
Synonym: -
Host Gene: PABPC1
Genomic location(hg19): chr8:101721360-101721451:-
Genomic location(hg38): chr8:100709132-100709223:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tumor tissue; adjacent non-tumor liver tissues
Cell lines:

MHCC-97h; HepG2
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: AR, ADAR1
Associated microRNA: -
Biological function: Inhibits HCC tumor growth and proliferation (tumor suppressor).
Molecular mechanism: AR upregulates ADAR1 p110, which suppresses circRNA circularization; CircARSP91 is downregulated by AR in an ADAR1-dependent manner. Downstream effector mechanism of CircARSP91 is not determined.
Biological pathway or process:

proliferation (inhibits); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Transfection; MTT; Colony Formation Assay; In Vivo Animal Model
Clinical significance:

-
Description:

CircARSP91 (hsa_circ_0085154), a PABPC1-derived circRNA, is suppressed by the AR/ADAR1 pathway in HCC. Functionally, CircARSP91 inhibits HCC cell proliferation and tumor growth in vitro and in an orthotopic mouse model, but its downstream molecular mechanism is not yet defined.
Confidence score:

0.5627
Other information
Title:

Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma.

Journal: Cell death & disease
Published: 2017
PubMed ID: 29144509
Study type:

combined biological and clinical study
Data availability: TCGA (http://cancergenome.nih.gov/)
Code availability: -