circRNA basic information
circBase ID: hsa_circ_0040039
Name: hsa_circ_SNTB2
Synonym: circ_0040039
Host Gene: syntrophin beta2
Genomic location(hg19): chr16:69279504-69318147:+
Genomic location(hg38): chr16:69245601-69284244:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0011385
MONDO name: intervertebral disk degenerative disorder
Disease details: intervertebral disk degeneration
Disease DO ID:
 90
Disease MeSH ID:
 D055959
Disease NCIt ID:
 C26983
Disease ICD11 ID:
 -
Disease OMIM ID:
 603932
Species: Human
Species details: Homo sapiens
Tissue specimen:

NP tissues
Cell lines:

NPCs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ESR1
Associated microRNA: miR-874-3p
Biological function: enhances NPC apoptosis and inhibits NPC growth; promotes NPC degeneration/aggravates IDD
Molecular mechanism: stabilization mechanism: circ_0040039 elevates miR-874-3p, which represses ESR1 expression
Biological pathway or process:

apoptosis (promotes); proliferation (inhibits); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot
Clinical significance:

-
Description:

circ_0040039 is upregulated in IDD and, in NPCs, increases miR-874-3p while repressing ESR1, consistent with a miRNA-stabilization model. Functionally, circ_0040039 promotes NPC apoptosis and inhibits NPC growth, suggesting it aggravates IDD through the miR-874-3p-ESR1 axis.
Confidence score:

0.5008
Other information
Title:

Circ_0040039 May Aggravate Intervertebral Disk Degeneration by Regulating the MiR-874-3p-ESR1 Pathway.

Journal: Frontiers in genetics
Published: 2021
PubMed ID: 34178027
Study type:

combined biological and clinical study
Data availability: GSE67566; GSE63492; GSE116726; GSE56081
Code availability: -