| Expression pattern: |
DN |
| Associated gene: |
Foxo3a, Foxo3a mRNA, Foxo3a protein |
| Associated microRNA: |
miR-182 |
| Biological function: |
circRNA CRIM1 acts as a tumor-suppressive circRNA in bladder cancer; its overexpression inhibits bladder cancer cell migration and invasion and is associated with distal migration. |
| Molecular mechanism: |
circRNA CRIM1 regulates bladder cancer migration and invasion through a miR-182/Foxo3a axis, negatively regulating miR-182 and increasing Foxo3a mRNA and protein expression. |
| Biological pathway or process: |
migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis; ROC Analysis |
| Clinical significance: |
circRNA CRIM1 expression was significantly associated with distal migration and may serve as a therapeutic target in bladder cancer. |
| Description: |
circRNA CRIM1 is down-regulated in bladder cancer tissues and cell lines and its expression is associated with distal migration. Functional assays indicate that circRNA CRIM1 overexpression suppresses bladder cancer cell migration and invasion. Mechanistically, circRNA CRIM1 acts through the miR-182/Foxo3a axis, reducing miR-182 and increasing Foxo3a mRNA/protein expression, suggesting tumor-suppressive and potential therapeutic relevance. |
| Confidence score: |
0.7078 |