| Expression pattern: |
UP |
| Associated gene: |
SARM1, Ago2 |
| Associated microRNA: |
miR-330-5p |
| Biological function: |
Promotes PCa cell proliferation, migration, invasion, cell cycle progression, tumorigenesis and tumor growth; inhibits apoptosis. |
| Molecular mechanism: |
circ_0044516 functions as a miR-330-5p sponge to release/increase SARM1 expression, thereby promoting malignant progression of PCa. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Potential therapeutic target for prospective PCa treatment. |
| Description: |
circ_0044516 is up-regulated in prostate cancer tissues and cell lines. It promotes malignant PCa behaviors and tumor growth by sponging miR-330-5p and increasing SARM1 expression, while circ_0044516 knockdown suppresses proliferation, migration, invasion and cell cycle progression and promotes apoptosis. |
| Confidence score: |
0.7052 |