| Expression pattern: |
UP |
| Associated gene: |
IGF1R |
| Associated microRNA: |
miR-502-5p |
| Biological function: |
Promotes AML cell proliferation, migration and invasion, suppresses apoptosis, and acts as a tumor promoter in AML. |
| Molecular mechanism: |
Hsa_circ_0003602 functions as a ceRNA sponge for miR-502-5p to regulate IGF1R expression through the hsa_circ_0003602/miR-502-5p/IGF1R axis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; Survival Analysis; Cohort Study |
| Clinical significance: |
High hsa_circ_0003602 expression predicted poor survival and was associated with shorter survival time in AML patients. |
| Description: |
hsa_circ_0003602 is up-regulated in AML bone marrow samples and AML cell lines, and high expression is associated with poor survival. Functionally, it promotes AML cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-502-5p to upregulate IGF1R, forming a hsa_circ_0003602/miR-502-5p/IGF1R axis that accelerates AML progression. |
| Confidence score: |
0.7779 |