circRNA basic information
circBase ID: -
Name: hsa_circ_FBXW8
Synonym: circFBXW8
Host Gene: FBXW8
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: Non-small cell lung carcinoma
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; neighboring healthy lung tissues; paracancerous normal lung tissues
Cell lines:

A549; PC9; BEAS-2B
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TRIM44
Associated microRNA: miR-370-3p
Biological function: Promotes NSCLC cell viability, colony formation, proliferation, migration, invasion, EMT-related malignant phenotypes and tumor formation, and inhibits apoptosis.
Molecular mechanism: circFBXW8 acts as a ceRNA sponge for miR-370-3p, thereby increasing TRIM44 expression and promoting NSCLC malignant progression; circFBXW8 secretion is mediated by exosomes.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); metastasis (promotes); ceRNA regulation (other); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis
Clinical significance:

-
Description:

circFBXW8 is up-regulated in NSCLC tissues, NSCLC cell lines, and exosomes from NSCLC cells. It functions as an oncogenic circRNA by sponging miR-370-3p to increase TRIM44 expression, thereby promoting proliferation, migration, invasion, EMT-like marker changes and xenograft tumor formation while inhibiting apoptosis. Its secretion is mediated by exosomes, and circFBXW8 inhibition is proposed as a potential therapeutic strategy for NSCLC.
Confidence score:

0.8006
Other information
Title:

CircFBXW8 Acts an Oncogenic Role in the Malignant Progression of Non-small Cell Lung Carcinoma by miR-370-3p-Dependent Regulation of TRIM44.

Journal: Biochemical genetics
Published: 2022
PubMed ID: 34988777
Study type:

combined biological and clinical study
Data availability: GSE101684; https://doi.org/10.1007/s10528-021-10177-1
Code availability: -