| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Circ-PVT1 potentially serves as a biomarker for AML disease risk and prognosis; higher expression is associated with increased BM blasts, FLT3-ITD mutation, poorer complete remission response, shorter EFS and shorter OS. |
| Molecular mechanism: |
Not experimentally determined in this study; the study reports clinical correlations of circ-PVT1 expression with AML risk, BM blasts, FLT3-ITD mutation, treatment response and survival. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis |
| Clinical significance: |
Circ-PVT1 could distinguish AML patients from disease controls and health donors; higher circ-PVT1 expression was correlated with lower CR, shorter EFS and OS, and independently predicted shorter EFS and OS. |
| Description: |
This study found that circ-PVT1 is up-regulated in bone marrow samples from AML patients compared with disease controls and healthy donors. Higher circ-PVT1 expression is associated with BM blasts, FLT3-ITD mutation, poorer complete remission response, shorter EFS and shorter OS, supporting its role as a prognostic biomarker in AML. |
| Confidence score: |
0.5918 |