| Expression pattern: |
UP |
| Associated gene: |
NRBP1 |
| Associated microRNA: |
miR-1253 |
| Biological function: |
circ_0062019 promotes PCa cell proliferation, migration, invasion, angiogenesis, EMT, cell cycle progression and tumour growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0062019 functions as a ceRNA/miRNA sponge by sequestering miR-1253, thereby up-regulating NRBP1 expression and promoting PCa progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); EMT (promotes); apoptosis (inhibits); cell cycle (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Tube Formation Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circ_0062019 may provide a potential biomarker or therapeutic target for PCa therapy. |
| Description: |
circ_0062019 is up-regulated in prostate cancer tissues and cell lines and acts as an oncogenic circRNA. Mechanistically, it is mainly cytoplasmic and sponges miR-1253 to increase NRBP1 expression, thereby promoting proliferation, migration, invasion, angiogenesis, EMT and tumour growth while suppressing apoptosis. Its circ_0062019/miR-1253/NRBP1 regulatory axis may represent a potential biomarker or therapeutic target for PCa. |
| Confidence score: |
0.8443 |