| Expression pattern: |
DN |
| Associated gene: |
E-cadherin, N-cadherin, vimentin, Slug |
| Associated microRNA: |
miR-1228 |
| Biological function: |
Inhibits proliferation, migration, invasion, metastasis and suppresses EMT; alters cell cycle distribution (G2/M arrest) in prostate cancer cells. |
| Molecular mechanism: |
Acts as a miRNA sponge by directly binding to miR-1228 and inhibiting its expression; miR-1228 reverses circRNA_100395 anti-tumor effects. |
| Biological pathway or process: |
proliferation (inhibits); cell cycle (other); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Cell Cycle Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
CircRNA_100395 expression was negatively correlated with tumor size, Gleason score, tumor stage, and lymph node metastasis. |
| Description: |
circRNA_100395 is down-regulated in prostate cancer tissues and cell lines and acts as a tumor suppressor. Its overexpression inhibits proliferation and metastatic behaviors and suppresses EMT, at least partly through direct binding/inhibition of miR-1228. |
| Confidence score: |
0.6521 |