circRNA basic information
circBase ID: hsa_circ_0075792
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr6:18212718-18214012:+
Genomic location(hg38): chr6:18212487-18213781:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood; serum; plasma; blood exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Diagnostic biomarker for HCC (serum/plasma/blood exosome-derived circRNA).
Molecular mechanism: Predicted to regulate target miRNAs and participate in cancer-related pathways (in silico).
Biological pathway or process:

VEGF/VEGFR (other); PI3K/AKT (other); PI3K/AKT/mTOR (other); Wnt/beta-catenin (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Shows diagnostic value (ROC) and positively correlated with TNM stage and tumor size.
Description:

hsa_circ_0075792 is up-regulated in serum/plasma (blood exosome-associated) from HCC patients and can help discriminate HCC from healthy controls by ROC analysis. Bioinformatics prediction links it to miRNA regulation and enrichment in VEGF/VEGFR, PI3K/Akt/mTOR and Wnt signaling.
Confidence score:

0.5047
Other information
Title:

Serum-derived three-circRNA signature as a diagnostic biomarker for hepatocellular carcinoma.

Journal: Cancer cell international
Published: 2020
PubMed ID: 32536814
Study type:

combined biological and clinical study
Data availability: exoRBase (http://www.exorbase.org/exoRBase/toIndex); available from the corresponding author on reasonable request
Code availability: -