| Expression pattern: |
UP |
| Associated gene: |
U2AF65, HuR, AGO2, PTB, eIF4AIII, UPF1 |
| Associated microRNA: |
miR-6757-3p, miR-146a-3p, miR-149-5p, miR-216b-5p, miR-5580-5p |
| Biological function: |
Potential diagnostic biomarker for PTC; higher serum exosomal levels correlate with lymph node metastasis and vascular invasion, suggesting involvement in PTC progression. |
| Molecular mechanism: |
Predicted interaction with miRNAs and RNA binding proteins; possible open reading frame and potential protein-coding capacity. |
| Biological pathway or process: |
metastasis (promotes); invasion (promotes); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Potential tumor marker to diagnose PTC, particularly more aggressive PTC; higher levels correlate with lymph node metastasis and vascular invasion. |
| Description: |
Exosomal hsa_circ_0082002 is up-regulated in serum from PTC patients and shows diagnostic potential for distinguishing PTC from healthy or benign thyroid tumor groups. Higher levels correlate with lymph node metastasis and vascular invasion, and bioinformatic analyses suggest possible roles through miRNA/RBP interactions and potential protein coding. |
| Confidence score: |
0.6841 |