| Expression pattern: |
DN |
| Associated gene: |
FOXJ3 |
| Associated microRNA: |
miR-106b-5p |
| Biological function: |
circSLC8A1 exhibits anti-tumor activity in NSCLC; overexpression inhibits NSCLC cell proliferation and invasion. |
| Molecular mechanism: |
circSLC8A1 sponges/binds miR-106b-5p and suppresses miR-106b-5p expression, thereby regulating the miR-106b-5p target gene FOXJ3 in NSCLC cells. |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
The circSLC8A1/miR-106b-5p/FOXJ3 axis may represent a promising therapeutic target for the management of NSCLC. |
| Description: |
circSLC8A1 is down-regulated in NSCLC tissues and cell lines. Functional experiments indicate that circSLC8A1 acts as a tumor suppressor by inhibiting NSCLC cell proliferation and invasion. Mechanistically, circSLC8A1 binds and suppresses miR-106b-5p, regulating the miR-106b-5p/FOXJ3 axis and suggesting therapeutic potential in NSCLC. |
| Confidence score: |
0.7551 |