circRNA basic information
circBase ID: hsa_circ_0029853
Name: hsa_circ_PAN3
Synonym: hsa_circRNA_101242
Host Gene: PAN3
Genomic location(hg19): chr13:28830428-28855516:+
Genomic location(hg38): chr13:28256291-28281379:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0800504
MONDO name: idiopathic pulmonary fibrosis
Disease details: idiopathic pulmonary fibrosis
Disease DO ID:
 -
Disease MeSH ID:
 D054990
Disease NCIt ID:
 C35716
Disease ICD11 ID:
 1074069640
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-21-3p, miR-338-3p
Biological function: Down-regulated in IPF plasma; proposed to act as a miRNA sponge (miR-21-3p/miR-338-3p) but direct binding and target mRNAs in IPF were not validated.
Molecular mechanism: Predicted ceRNA interaction with miR-21-3p and miR-338-3p; not experimentally validated in this study.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; divergent primers PCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential biomarker for pulmonary fibrosis (proposed).
Description:

hsa_circRNA_101242 is down-regulated in IPF plasma and is predicted to bind miR-21-3p and miR-338-3p, but the direct interaction and downstream targets in IPF were not confirmed in this study.
Confidence score:

0.585
Other information
Title:

Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis.

Journal: International journal of molecular medicine
Published: 2018
PubMed ID: 30272257
Study type:

combined biological and clinical study
Data availability: GSE102660
Code availability: -