| Expression pattern: |
UP |
| Associated gene: |
ROR1 |
| Associated microRNA: |
miR-30a-5p |
| Biological function: |
promotes EGFR-TKIs resistance and proliferation; inhibits apoptosis in NSCLC cells |
| Molecular mechanism: |
Exosomal circRNA_102481 acts as a miR-30a-5p sponge to upregulate ROR1 expression, contributing to EGFR-TKIs resistance. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; Western Blot; Survival Analysis |
| Clinical significance: |
High exosomal circRNA_102481 is associated with TNM stage, tumor differentiation status, brain metastasis, and shorter PFS and OS; may serve as a diagnostic biomarker and therapeutic target for EGFR-TKIs resistance in NSCLC. |
| Description: |
This study reports that tumor-derived exosomal circRNA_102481 is up-regulated in EGFR-TKI-resistant NSCLC and promotes resistance by enhancing proliferation and inhibiting apoptosis. Mechanistically, circRNA_102481 functions as a ceRNA that sponges miR-30a-5p to increase ROR1 expression. High exosomal circRNA_102481 correlates with adverse clinicopathological features and shorter PFS/OS. |
| Confidence score: |
0.814 |