| Expression pattern: |
UP |
| Associated gene: |
THBS2, Ago2 |
| Associated microRNA: |
miR-598 |
| Biological function: |
Inhibits radiosensitivity by promoting proliferation and suppressing apoptosis; circ_0007580 knockdown enhances radiosensitivity. |
| Molecular mechanism: |
Acts as a miR-598 sponge to regulate THBS2 (ceRNA-like mechanism), affecting radiosensitivity. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Colony Formation Assay; CCK8; Annexin V/PI Flow Cytometry; Western Blot; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
Potential therapeutic target to improve radiosensitivity (overcome radioresistance) in NSCLC. |
| Description: |
circ_0007580 is up-regulated in NSCLC (especially radioresistant tissues) and promotes radioresistance. Its knockdown enhances radiosensitivity by inhibiting proliferation and promoting apoptosis, mainly via sponging miR-598 to upregulate THBS2 (circ_0007580/miR-598/THBS2 axis). |
| Confidence score: |
0.7412 |