| Expression pattern: |
UP |
| Associated gene: |
MYD88, NF-kappaB signalling, UQCRC2 |
| Associated microRNA: |
miR-495-3p |
| Biological function: |
Circ-UQCRC2 aggravates LPS-induced injury in 16HBE cells by promoting apoptosis, inflammatory response, and oxidative stress while suppressing cell viability. |
| Molecular mechanism: |
Circ-UQCRC2 acts as a molecular sponge for miR-495-3p, thereby up-regulating MYD88 and activating NF-kappaB signalling to mediate inflammatory response and oxidative stress. |
| Biological pathway or process: |
ceRNA regulation (other); NF-kappaB (promotes); apoptosis (promotes); inflammation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; ELISA; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Circ-UQCRC2, miR-495-3p and MYD88 might be promising therapeutic targets for infantile pneumonia. |
| Description: |
Circ-UQCRC2 is up-regulated in LPS-induced 16HBE pneumonia cell models and aggravates cell injury. Mechanistically, circ-UQCRC2 sponges miR-495-3p to increase MYD88 expression and promote NF-kappaB-associated inflammatory response, apoptosis, and oxidative stress. Silencing circ-UQCRC2 protects 16HBE cells from LPS-mediated damage, suggesting potential therapeutic relevance in infantile pneumonia. |
| Confidence score: |
0.7615 |