circRNA basic information
circBase ID: -
Name: hsa_circ_CBL
Synonym: -
Host Gene: CBL
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HCT116; HT29; SW620; NCM460; HEK293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: YWHAE, AGO2, p53
Associated microRNA: miR-6778-5p
Biological function: Suppresses CRC cell proliferation under carbon ion irradiation.
Molecular mechanism: Acts as a competing endogenous RNA (ceRNA) that sponges miR-6778-5p to regulate YWHAE, involving the p53 pathway.
Biological pathway or process:

proliferation (inhibits); p53 signaling (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

In CRC cell lines exposed to carbon ion irradiation, circRNA CBL.11 is induced and suppresses proliferation. Mechanistically, it sponges miR-6778-5p to upregulate YWHAE and involves the p53 pathway.
Confidence score:

0.7807
Other information
Title:

CircRNA CBL.11 suppresses cell proliferation by sponging miR-6778-5p in colorectal cancer.

Journal: BMC cancer
Published: 2019
PubMed ID: 31438886
Study type:

biological research
Data availability: All data generated or analyzed during this study are included in this published article [and its supplementary information files].
Code availability: -