circRNA basic information
circBase ID: hsa_circ_0088233
Name: hsa_circ_PAPPA
Synonym: -
Host Gene: PAPPA
Genomic location(hg19): chr9:119033603-119115195:+
Genomic location(hg38): chr9:116271324-116352916:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PCa tissues; para-cancer normal tissues; PCa tissue specimens; adjacent healthy tissue specimens; tumour tissues
Cell lines:

DU145; 22RV1; LNCaP; C4-2; RWPE-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FKBP1A
Associated microRNA: miR-515-5p
Biological function: Circ-PAPPA promotes PCa cell viability, proliferation, migration, invasion, glycolysis and in vivo tumour growth, and inhibits apoptosis.
Molecular mechanism: Circ-PAPPA acts as a ceRNA by sequestering miR-515-5p, thereby inducing FKBP1A expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model
Clinical significance:

Up-regulation of circ-PAPPA in PCa patients was associated with increased Gleason score, positive lymph node metastasis and advanced clinical T stage.
Description:

Circ-PAPPA (hsa_circ_0088233) is up-regulated in prostate cancer tissues and cell lines. It promotes malignant phenotypes including proliferation, migration, invasion, glycolysis and xenograft tumour growth while suppressing apoptosis, mainly through sponging miR-515-5p to increase FKBP1A expression. Higher circ-PAPPA expression is associated with aggressive clinicopathological features such as higher Gleason score, lymph node metastasis and advanced clinical T stage.
Confidence score:

0.8006
Other information
Title:

CircRNA pappalysin 1 facilitates prostate cancer development through miR-515-5p/FKBP1A axis.

Journal: Andrologia
Published: 2021
PubMed ID: 34469009
Study type:

combined biological and clinical study
Data availability: All data generated or analysed during this study are included in this published article.
Code availability: -