circRNA basic information
circBase ID: -
Name: hsa_circ_CDR1AS
Synonym: ciRS-7
Host Gene: CDR1AS
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005178
MONDO name: osteoarthritis
Disease details: osteoarthritis
Disease DO ID:
 8398
Disease MeSH ID:
 D010003
Disease NCIt ID:
 C3293
Disease ICD11 ID:
 558562409
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

articular cartilage
Cell lines:

C28/I2; 293T
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: IL-17A, PI3K, Akt, mTOR
Associated microRNA: miR-7
Biological function: Regulates cartilage degradation and autophagy impairment in osteoarthritis chondrocytes, linked to IL-17A-mediated activation of PI3K/AKT/mTOR signaling.
Molecular mechanism: ciRS-7 is discussed as part of a ciRS-7/miR-7 axis affecting IL-17A levels and downstream PI3K/AKT/mTOR phosphorylation, influencing autophagy and extracellular matrix degradation markers (e.g., MMP3, MMP13, ADAMTS5).
Biological pathway or process:

PI3K/AKT/mTOR (other); autophagy (other); cartilage degradation (other); IL-17 signaling (other); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; Western Blot; ELISA; Bioinformatics Analysis; RNA-seq; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); IF (Immunofluorescence)
Clinical significance:

-
Description:

This study investigates ciRS-7 as part of the ciRS-7/miR-7 axis in osteoarthritis, linking altered axis status to cartilage matrix degradation and impaired autophagy. The axis is connected mechanistically to IL-17A-associated PI3K/AKT/mTOR pathway activation in IL-1beta-stimulated chondrocytes, with supportive in vivo findings in a DMM rat OA model (via miR-7 modulation).
Confidence score:

0.6111
Other information
Title:

Down-regulated ciRS-7/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis.

Journal: Aging
Published: 2020
PubMed ID: 33099538
Study type:

combined biological and clinical study
Data availability: -
Code availability: -