circRNA basic information
circBase ID: hsa_circ_0053441
Name: hsa_circ_BIRC6
Synonym: circRNA BIRC6
Host Gene: BIRC6
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; adjacent non-cancerous tissues; benign gastric mucosa tissues; formalin-fixed and paraffin-embedded cancerous and matched neighboring non-cancerous tissues; xenograft tumour samples
Cell lines:

AGS; HGC27; MKN1; MKN45; 293 T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: GRIN2D, CAV1, AGO2
Associated microRNA: miR-488
Biological function: Promotes gastric cancer cell proliferation, migration, invasion and tumorigenesis, while inhibiting apoptosis and reducing autophagy levels.
Molecular mechanism: circBIRC6 functions as a ceRNA sponge for miR-488, upregulates GRIN2D, enhances CAV1 expression, and inhibits autophagy, thereby promoting malignant progression of gastric cancer.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); autophagy (inhibits); metastasis (promotes); other pathway/process (promotes)
Detected method:
Q
H
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; circRNA-seq; RT-qPCR; FISH / smFISH; ISH (In Situ Hybridization); IHC (Immunohistochemistry); Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; Western Blot; Cohort Study; Survival Analysis; Bioinformatics Analysis; RNA-seq
Clinical significance:

High circBIRC6 expression was associated with depth of tumour invasion, TNM stage, and poor overall survival; circBIRC6 is proposed as a potential treatment target and independent prognostic factor for gastric cancer patients.
Description:

circBIRC6 is up-regulated in gastric cancer and predicts poor overall survival. It promotes proliferation, migration, invasion, and tumor growth by sponging miR-488, increasing GRIN2D and CAV1 expression, and inhibiting autophagy, making it a potential therapeutic target and independent prognostic factor.
Confidence score:

0.8897
Other information
Title:

CircBIRC6 facilitates the malignant progression via miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric cancer.

Journal: Pharmacological research
Published: 2024
PubMed ID: 38438090
Study type:

combined biological and clinical study
Data availability: Data will be made available on request; GSE121445; GSE131481; GSE83521; Supplementary data associated with this article can be found in the online version at doi:10.1016/j.phrs.2024.107127
Code availability: -