circRNA basic information
circBase ID: hsa_circ_0088088
Name: hsa_circ_HSDL2
Synonym: -
Host Gene: HSDL2
Genomic location(hg19): chr9:115166274-115171301:+
Genomic location(hg38): chr9:112403994-112409021:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

human breast malignancy samples; neighboring nontumor tissues; tumor tissues; adjacent nontumor tissues
Cell lines:

MCF10A; MCF-7; MDA-MB-231; H293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: EIF4A3
Associated microRNA: miR-135-5p
Biological function: Promotes breast cancer cell growth, proliferation, migration, invasion and metastasis; inhibits apoptosis; acts as an oncogene in breast cancer cells; associated with unfavorable prognosis.
Molecular mechanism: EIF4A3 positively regulates hsa_circ_0088088 biogenesis/expression, and hsa_circ_0088088 acts as a ceRNA by sponging miR-135-5p to promote breast cancer carcinogenesis.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot
Clinical significance:

High hsa_circ_0088088 expression is associated with unfavorable prognosis and decreased overall survival in breast cancer patients.
Description:

hsa_circ_0088088 is up-regulated in breast cancer tissues and cell lines, and high expression predicts poor overall survival. Functionally, it promotes breast cancer cell growth, proliferation, migration, invasion and metastasis while suppressing apoptosis. Mechanistically, EIF4A3 positively regulates hsa_circ_0088088 biogenesis/expression, and hsa_circ_0088088 promotes carcinogenesis by sponging miR-135-5p.
Confidence score:

0.7962
Other information
Title:

EIF4A3-mediated hsa_circ_0088088 promotes the carcinogenesis of breast cancer by sponging miR-135-5p.

Journal: Journal of biochemical and molecular toxicology
Published: 2021
PubMed ID: 34463003
Study type:

combined biological and clinical study
Data availability: The corresponding author can provide the analyzed data.
Code availability: -