| Expression pattern: |
UP |
| Associated gene: |
LDHA, CyclinD1, Bax |
| Associated microRNA: |
miR-149-5p |
| Biological function: |
Promotes GC cell proliferation, migration, invasion, angiogenesis, tumor growth and radioresistance, and suppresses apoptosis and radiosensitivity. |
| Molecular mechanism: |
circ-DONSON acts as a miRNA sponge for miR-149-5p and indirectly upregulates LDHA, forming a circ-DONSON/miR-149-5p/LDHA axis that promotes GC progression and radioresistance. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); angiogenesis (promotes); apoptosis (inhibits); radioresistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
May serve as a promising biomarker and treatment target for GC. |
| Description: |
circ-DONSON is up-regulated in gastric cancer tissues and cell lines. It promotes malignant GC progression by enhancing proliferation, migration, invasion, angiogenesis, tumor growth and radioresistance while inhibiting apoptosis. Mechanistically, circ-DONSON sponges miR-149-5p to upregulate LDHA through the circ-DONSON/miR-149-5p/LDHA axis. |
| Confidence score: |
0.7132 |