| Expression pattern: |
DN |
| Associated gene: |
48 genes |
| Associated microRNA: |
Hsa-miR-140-5p, Hsa-miR-197-3p, Hsa-miR-338-3p |
| Biological function: |
Inhibits proliferation and promotes apoptosis in ccRCC cells (acts as an anti-oncogene). |
| Molecular mechanism: |
Predicted ceRNA mechanism via sponging miRNAs (Hsa-miR-140-5p, Hsa-miR-197-3p, Hsa-miR-338-3p) and regulating downstream target genes; pathway enrichment suggests involvement in cancer-related pathways. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); cell cycle (other); MAPK (other); TGF-beta/SMAD (other); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis; Survival Analysis; ROC Analysis |
| Clinical significance: |
Down-regulation is linked to aggressive clinicopathological characteristics; low level is negatively correlated with overall survival; ROC AUC indicates diagnostic value. |
| Description: |
Hsa_circ_0001451 is down-regulated in ccRCC tissues and RCC cell lines and functions as a tumor-suppressive circRNA. Its knockdown increases ccRCC cell proliferation and reduces apoptosis. The study also predicts a ceRNA network involving Hsa-miR-140-5p, Hsa-miR-197-3p, and Hsa-miR-338-3p, and suggests potential diagnostic/prognostic value. |
| Confidence score: |
0.6806 |