| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-370-3p |
| Biological function: |
CircUBAP2 promotes proliferation and invasion and inhibits apoptosis in thyroid cancer cells. |
| Molecular mechanism: |
CircUBAP2 acts as a miRNA sponge for miR-370-3p and inhibits miR-370-3p expression, thereby regulating proliferation, apoptosis, and invasion in TC cells. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Actinomycin D / DRB Stability Assay; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot |
| Clinical significance: |
circUBAP2 expression was associated with lymph node metastasis and may represent a promising therapeutic target for TC. |
| Description: |
circUBAP2/hsa_circ_0003141 is upregulated in thyroid cancer and papillary thyroid cancer tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-370-3p, thereby promoting TC cell proliferation and invasion while suppressing apoptosis. Clinically, circUBAP2 expression was associated with lymph node metastasis and may serve as a therapeutic target. |
| Confidence score: |
0.8267 |