| Expression pattern: |
UP |
| Associated gene: |
CXCR4 |
| Associated microRNA: |
miR-340-5p |
| Biological function: |
circN4BP2L2 promotes CRC cell proliferation, migration, invasion, tumor growth and lung metastasis, and inhibits apoptosis. |
| Molecular mechanism: |
circN4BP2L2 acts as a ceRNA/molecular sponge for miR-340-5p, relieving miR-340-5p-mediated repression and promoting CXCR4 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circN4BP2L2 was closely correlated with tumor stage and lymph node metastasis and may be a promising biomarker and target for CRC treatment. |
| Description: |
circN4BP2L2/hsa_circ_0000471 is upregulated in colorectal cancer tissues and cell lines and correlates with advanced tumor stage and lymph node metastasis. Functionally, it promotes CRC proliferation, migration, invasion, tumor growth and lung metastasis while inhibiting apoptosis. Mechanistically, circN4BP2L2 acts as a ceRNA sponge for miR-340-5p to increase CXCR4 expression, supporting its potential as a CRC biomarker and therapeutic target. |
| Confidence score: |
0.7184 |