circRNA basic information
circBase ID: hsa_circ_0003528
Name: hsa_circ_SEC24A
Synonym: -
Host Gene: SEC24A
Genomic location(hg19): chr5:134032815-134044578:+
Genomic location(hg38): chr5:134697125-134708888:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0100481
MONDO name: active tuberculosis
Disease details: active tuberculosis
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Candidate plasma diagnostic biomarker for TB (ROC AUC reported); not associated with radiological severity score.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Shows diagnostic value for TB in ROC analysis (AUC 0.768).
Description:

hsa_circ_0003528 is up-regulated in plasma of active TB patients based on microarray and RT-qPCR validation. It has moderate diagnostic performance in ROC analysis but does not correlate with radiological severity score in this study.
Confidence score:

0.5047
Other information
Title:

Plasma Circular RNAs hsa_circ_0001953 and hsa_circ_0009024 as Diagnostic Biomarkers for Active Tuberculosis.

Journal: Frontiers in microbiology
Published: 2018
PubMed ID: 30214434
Study type:

combined biological and clinical study
Data availability: https://www.frontiersin.org/articles/10.3389/fmicb.2018.02010/full#supplementary-material
Code availability: -