| Expression pattern: |
UP |
| Associated gene: |
CPT1A, AGO2 |
| Associated microRNA: |
miR-5572, miR-6855-5p |
| Biological function: |
Promotes gastric cancer cell migration, invasion and lymphatic metastasis by inducing fatty acid oxidation (FAO) metabolic reprogramming (in GC-MSCs and gastric cancer cells). |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-5572 and miR-6855-5p to upregulate CPT1A, increasing FAO activity and promoting metastasis-related phenotypes. |
| Biological pathway or process: |
lipid metabolism (promotes); metastasis (promotes); invasion (promotes); migration (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Transfection; Transwell Assay; Western Blot; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Deregulated in gastric cancer tissues and associated with lymph node metastasis and patient prognosis. |
| Description: |
This study identifies circ_0024107 as an upregulated circRNA in gastric cancer tissues and GC-derived MSCs that promotes gastric cancer cell migration/invasion and lymphatic metastasis. circ_0024107 mainly localizes to the cytoplasm and functions as a miRNA sponge for miR-5572 and miR-6855-5p, thereby upregulating CPT1A to enhance fatty acid oxidation metabolic reprogramming. The circ_0024107/miR-5572/6855-5p/CPT1A axis is linked to lymph node metastasis and patient prognosis. |
| Confidence score: |
0.8746 |