circRNA basic information
circBase ID: hsa_circ_0003192
Name: hsa_circ_WDR33
Synonym: circRNA Wdr33
Host Gene: Wdr33
Genomic location(hg19): chr2:128520635-128528578:-
Genomic location(hg38): chr2:127763061-127771004:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005812
MONDO name: influenza
Disease details: influenza A virus-induced lung injury
Disease DO ID:
 8469
Disease MeSH ID:
 D007251; D009976
Disease NCIt ID:
 C53482
Disease ICD11 ID:
 145723401
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung tissues; plasma
Cell lines:

-
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miRNA-543, miRNA-130b
Biological function: potential role in IAV-induced lung injury/ARDS (bioinformatics-predicted involvement in mitochondrial function and superoxide metabolic process)
Molecular mechanism: predicted circRNA-miRNA interaction (miRNA sponge/ceRNA-like) network; downstream pathways inferred by GO/KEGG enrichment
Biological pathway or process:

mitochondrial function (other); oxidative phosphorylation (other); Hippo/YAP (other); Notch (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; In Vivo Animal Model; H&E Staining
Clinical significance:

Plasma circRNA Wdr33 presented differential expression in patients with IAV-induced ARDS compared to control.
Description:

CircRNA Wdr33 (mmu_circ_0000858/hsa_circ_0003192) is down-regulated in IAV-induced lung injury in mice and in plasma from IAV-induced ARDS patients. The study builds predicted circRNA-miRNA interaction networks and enrichment results implicating processes such as mitochondrial function/superoxide metabolism and pathways including Hippo, oxidative phosphorylation, and Notch, suggesting potential regulatory involvement in lung injury.
Confidence score:

0.5623
Other information
Title:

CircRNA expression profiling and bioinformatics analysis indicate the potential biological role and clinical significance of circRNA in influenza A virus-induced lung injury.

Journal: Journal of biosciences
Published: 2021
PubMed ID: 33969826
Study type:

combined biological and clinical study
Data availability: 10.1007/s12038-021-00152-8 (Electronic supplementary material)
Code availability: -