circRNA basic information
circBase ID: hsa_circ_0056285
Name: hsa_circ_RALB
Synonym: circ_0056285
Host Gene: RALB
Genomic location(hg19): chr2:121036193-121047333:+
Genomic location(hg38): chr2:120278617-120289757:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: Non-Small-Cell Lung Cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Serves as a serum exosomal diagnostic biomarker for NSCLC and early-stage NSCLC; its expression is negatively correlated with NSCLC stage progression and lymphatic metastasis.
Molecular mechanism: Exosomal circRNA biomarker; potential miRNA-binding mechanism was predicted, but the functional mechanism is unknown.
Biological pathway or process:

metastasis (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

circ_0056285 showed diagnostic value for distinguishing NSCLC patients from healthy controls and early-stage NSCLC from healthy controls; combined with circ_0007761, it distinguished NSCLC cases from TB controls; its expression was associated with advanced NSCLC stage and lymph node metastasis.
Description:

circ_0056285 is a down-regulated serum exosomal circRNA in NSCLC. It was validated by qPCR and splice-junction sequencing, showed diagnostic utility for NSCLC, and was negatively correlated with disease stage progression and lymphatic metastasis.
Confidence score:

0.6556
Other information
Title:

Identification of Three Circular RNA Cargoes in Serum Exosomes as Diagnostic Biomarkers of Non-Small-Cell Lung Cancer in the Chinese Population.

Journal: The Journal of molecular diagnostics : JMD
Published: 2020
PubMed ID: 32535085
Study type:

combined biological and clinical study
Data availability: -
Code availability: -