| Expression pattern: |
UP |
| Associated gene: |
AKT3, Ago2 |
| Associated microRNA: |
miR-646 |
| Biological function: |
promotes proliferation, migration, and invasion; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0016760 sponges miR-646 to increase AKT3 expression (Ago2-dependent). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); PI3K/AKT (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation; Bioinformatics Analysis; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
circ_0016760 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes NSCLC proliferation, migration/invasion and tumor growth while inhibiting apoptosis by sponging miR-646 to upregulate AKT3 (circ_0016760/miR-646/AKT3 axis). |
| Confidence score: |
0.7855 |