| Expression pattern: |
UP |
| Associated gene: |
DCP1A |
| Associated microRNA: |
miR-760 |
| Biological function: |
promotes proliferation, chemoradiotherapy resistance, and tumor growth; inhibits apoptosis; promotes cell cycle progression |
| Molecular mechanism: |
ceRNA mechanism: circ_0007031 sponges miR-760 to derepress DCP1A, promoting CRC growth and chemoradiotherapy resistance |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); chemoresistance (promotes); radioresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Clinical Sample Validation; In Vivo Animal Model |
| Clinical significance: |
high expression of circ_0007031 was markedly related to the tumor size, TNM stage and CEA of CRC patients |
| Description: |
circ_0007031 is up-regulated in colorectal cancer, enriched in the cytoplasm, and promotes proliferation and chemoradiotherapy resistance. Mechanistically, it sponges miR-760 to increase DCP1A expression, thereby enhancing 5-Fu and radiation resistance; silencing circ_0007031 increases treatment sensitivity in vitro and in xenograft tumors. |
| Confidence score: |
0.7635 |