circRNA basic information
circBase ID: hsa_circ_0000417
Name: hsa_circ_CPSF6
Synonym: -
Host Gene: CPSF6
Genomic location(hg19): chr12:69644908-69656342:+
Genomic location(hg38): chr12:69251128-69262562:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary HCC tissues; adjacent normal tissues; normal hepatocytes
Cell lines:

HepG2; JHH-4; JHH-5
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential biomarker for the specific diagnosis of HCC; in combination with hsa_circ_0001438, it may help distinguish between undifferentiated and highly differentiated HCC.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; RNA-seq; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Potential diagnostic biomarker for HCC; ROC AUC value was 0.738.
Description:

hsa_circ_0000417 was identified from public RNA-seq data as upregulated in primary HCC tissues and was confirmed by RT-qPCR to be elevated in HCC cell lines, especially JHH-5. The study proposes hsa_circ_0000417 as a potential HCC diagnostic biomarker and suggests it may help distinguish differentiation status when combined with hsa_circ_0001438.
Confidence score:

0.6193
Other information
Title:

Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma.

Journal: International journal of experimental pathology
Published: 2022
PubMed ID: 36153641
Study type:

combined bioinformatics and biological research
Data availability: GSE77509; CIRCpedia v2
Code availability: -