circRNA basic information
circBase ID: hsa_circ_0006404
Name: hsa_circ_FOXO3
Synonym: circRNA_0006404
Host Gene: FOXO3
Genomic location(hg19): chr6:108984657-108986092:+
Genomic location(hg38): chr6:108663454-108664889:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

mouse tissue; tumor tissue
Cell lines:

SKOV3; SKOV3-R
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: DKK3, p-GP
Associated microRNA: miR-346
Biological function: hsa_circ_0006404 acts as a docetaxel-sensitizing and tumor-suppressive circRNA in ovarian cancer models; its knockdown increases p-GP expression, enhances proliferation and tumor growth, and decreases apoptosis under DTX treatment.
Molecular mechanism: hsa_circ_0006404 interacts with miR-346 and regulates DKK3 and p-GP expression, forming the hsa_circ_0006404/miR-346/DKK3/p-GP axis in ovarian cancer response to DTX.
Biological pathway or process:

drug resistance (inhibits); apoptosis (promotes); proliferation (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; Transfection; Annexin V/PI Flow Cytometry; TUNEL; Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0006404 is down-regulated in DTX-resistant SKOV3-R ovarian cancer cells. The study supports a hsa_circ_0006404/miR-346/DKK3/p-GP axis in which hsa_circ_0006404 inhibits p-GP-associated docetaxel resistance, suppresses proliferation and tumor growth, and promotes apoptosis under DTX treatment.
Confidence score:

0.5607
Other information
Title:

Hsa_circ_0006404 and hsa_circ_0000735 Regulated Ovarian Cancer Response to Docetaxel Treatment via Regulating p-GP Expression.

Journal: Biochemical genetics
Published: 2022
PubMed ID: 34255218
Study type:

biological research
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -