| Expression pattern: |
UP |
| Associated gene: |
AQP3, Ago2 |
| Associated microRNA: |
miR-345-5p |
| Biological function: |
Circ-STIL promotes HCC cell proliferation, migration, invasion, tumor growth and metastasis-related malignant progression, and inhibits apoptosis. |
| Molecular mechanism: |
Circ-STIL acts as a ceRNA by sponging miR-345-5p to enhance AQP3 expression, thereby promoting HCC progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Circ-STIL may provide a promising target for HCC therapy. |
| Description: |
Circ-STIL is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It promotes HCC proliferation, migration, invasion and in vivo tumor growth while suppressing apoptosis, mainly through a ceRNA mechanism in which circ-STIL sponges miR-345-5p to increase AQP3 expression. The study suggests circ-STIL as a potential therapeutic target for HCC. |
| Confidence score: |
0.8175 |