circRNA basic information
circBase ID: -
Name: hsa_circ_TNFRSF21
Synonym: circTNFRSF21
Host Gene: TNFRSF21
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

NCI-H1792
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: TNFRSF21
Associated microRNA: -
Biological function: increases colony formation; may be translated into a 42 kDa protein
Molecular mechanism: circRNA translation with an open reading frame crossing the backsplice site twice in two different reading frames
Biological pathway or process:

proliferation (promotes); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Transfection; Western Blot; Bioinformatics Analysis; Colony Formation Assay
Clinical significance:

-
Description:

circTNFRSF21 is differentially expressed between tumor-derived and non-transformed lung cell lines, promotes colony formation when overexpressed, and has coding potential consistent with translation into an ~42 kDa protein crossing the backsplice site in two reading frames.
Confidence score:

0.642
Other information
Title:

The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells.

Journal: Cancers
Published: 2020
PubMed ID: 32353949
Study type:

biological research
Data availability: Supplementary Table S2; Supplementary Table S3; Supplementary Table S4; Supplementary Table S5; Supplementary Figure S1
Code availability: -