| Expression pattern: |
UP |
| Associated gene: |
XRCC5 |
| Associated microRNA: |
miR-532-5p |
| Biological function: |
promotes proliferation, migration and invasion; promotes tumor growth; promotes metastasis |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-532-5p to upregulate XRCC5 (ceRNA axis); transported via exosomes |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; MTT; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
High circANTXR1 expression was associated with lower overall survival; serum exosome circANTXR1 showed diagnostic significance (AUC=0.76). |
| Description: |
circANTXR1 is up-regulated in HCC tissues/cells and promotes proliferation and metastasis. Mechanistically, it sponges miR-532-5p to increase XRCC5 expression, and it is transported via exosomes; serum exosomal circANTXR1 shows diagnostic potential and high tumor expression predicts worse survival. |
| Confidence score: |
0.8283 |